Loxagyl 400mg Tablet contains Metronidazole as its active ingredient. It’s an antibiotic and antiprotozoal medication used to treat various bacterial and parasitic infections. Loxagyl is effective against anaerobic bacteria and certain parasites. Uses Loxagyl 400mg Tablet is primarily used to treat: Bacterial infections of the stomach, skin, joints, and respiratory tract Parasitic infections such as amoebiasis and giardiasis Dental infections Bacterial vaginosis Prevention of infections after certain surgeries Benefits Effective against anaerobic bacteria and protozoa Treats wide range of infections including dental and gynecological Rapid symptom relief in most infections Well-absorbed when taken orally Penetrates well into tissues and body fluids Cost-effective treatment option Available in multiple formulations Can be used in combination therapies Generally well-tolerated when used appropriately How It Works Metronidazole is converted to its active form inside anaerobic bacteria and protozoa. It interferes with DNA synthesis by binding to DNA strands, causing cell death. This selective action makes it highly effective against anaerobic organisms while having minimal impact on normal aerobic bacteria. Dosage Indication Adult Dosage Treatment Duration Bacterial infections 400mg 2-3× daily 7-10 days Amoebiasis 400mg 3× daily 5-10 days Trichomoniasis 400mg 2× daily 7 days Take Loxagyl with or after meals to reduce stomach irritation. Swallow tablets whole with water. Duration of Action Loxagyl begins working within hours of administration, with peak blood levels reached in 1-2 hours. Therapeutic effects are usually noticeable within 24-48 hours. The medication has a half-life of 6-8 hours, requiring multiple daily doses for optimal effectiveness. Side Effects Common side effects include nausea, metallic taste, loss of appetite, and mild stomach upset. Some patients may experience headache, dizziness, or dark-colored urine. Serious side effects like peripheral neuropathy or seizures are rare but require immediate medical attention. Warning Avoid alcohol consumption during treatment and for 48 hours after completion, as it can cause severe nausea, vomiting, and flushing. Loxagyl may cause dizziness affecting driving ability. Long-term use may lead to peripheral neuropathy. Inform doctor of any neurological symptoms during treatment. Pregnancy and Breastfeeding Loxagyl should be avoided during the first trimester of pregnancy unless benefits clearly outweigh risks. It can be used in later pregnancy when necessary. The medication passes into breast milk, so breastfeeding should be discontinued during treatment and for 12-24 hours after the last dose. Interaction Severe reaction when combined with alcohol or alcohol-containing products May enhance effects of warfarin and other anticoagulants Can increase lithium levels leading to toxicity Possible interaction with certain seizure medications May reduce effectiveness of hormonal contraceptives Potential interaction with cyclosporine Precaution Use with caution in patients with liver disease, neurological disorders, or blood disorders. Monitor for signs of peripheral neuropathy during prolonged treatment. Avoid in patients with known hypersensitivity to metronidazole. Regular monitoring may be needed for extended treatment courses. Important Information Complete the full course even if symptoms improve early. Loxagyl may cause false-positive results in certain laboratory tests. Store at room temperature away from moisture and heat. Sexual partners should be treated simultaneously for sexually transmitted infections. Avoid alcohol-containing medications, mouthwashes, and foods during treatment. Product Image Gallery Customer questions & answers Customers say Customers say they have concerns about taking Loxagyl 400mg while being sexually active, with advice to avoid sexual intercourse during treatment for certain conditions. AI Generated from customer reviews and questions Select to learn more Sex During Treatment (1) 1 customer mentions “Sex During Treatment” 1 positive × “...ised to avoid sexual intercourse during treatment, especially if you're being treated for a vaginal or sexually transmitted infection. This helps ensure proper...” Read more › Have a question about this product? Your question * Name * Email * Notify me when answered. Recent Popular Unanswered Can you still have sex? 0 votes JB John Bratton July 31, 2025 10:25 pm Q Can you still have sex? answer now Asked by John Bratton on July 31, 2025 10:25 pm Verified by Pharmacist Hello John, Yes, you can still have sex while taking Loxagyl 400mg , but it’s generally advised to avoid sexual intercourse during treatment, especially if you're being treated for a vaginal or sexually transmitted infection. This helps ensure proper healing and prevents reinfection or transmission. 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